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104 Enhancing tissue-specificity and cell-specific targeting Active targeting The development of engineered nanoparticle delivery systems has introduced powerful strategies to overcome the longstanding obstacle of non-specific biodistribution of therapeutic drugs and nucleic acids
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A follow-up study suggested the involvement of PLD1 (Phospholipase D1)—an enzyme previously linked to mTOR complex stability and activity, via the production of phosphatidic acid (PA) (Toschi et al., 2009
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