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Although anemia is often a symptom, the condition is actually the end stage of an autoimmune inflammation of the stomach known as autoimmune atrophic gastritis, resulting in destruction of stomach cells by one's own antibodies (autoantibodies)

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Concurrent administration with cysteine or N-acetylcysteine enhances hepatic sulfate production, which could alter acetaminophen metabolism and should be considered when treating patients with chronic pain requiring frequent analgesia