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In STZ-diabetic rats, apelin expression increases in MΓΌller cells and retinal vessels, and exogenous apelin promotes cell proliferation and GFAP/VEGF upregulation, while the apelin receptor antagonist F13A suppresses MΓΌller cell proliferation and reduces gliotic and angiogenic markers, suggesting a pathogenic role in proliferative stages (243, 244)
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