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Likewise, in an in vitro insulin-resistant neural stem and progenitor cell (NSPC) model, insulin and palmitic acid (IPA) induced senescence characterized by upregulation of p16 INK4a and p21, and impairment of IRS-1/Forkhead box O (FoxO) signaling, which reduced FoxO1/3a recruitment to proliferation-related genes such as Cyclin D and SRY-box transcription factor 2 (SOX2)
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